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Vivafarma Solutions Ltd.
Vivafarma Solutions Ltd. - Sofia

Top Folate 60 capsules

18.60 BGN
Dosage form:
Active ingredient:
Quatrefolic (6S) - 5 метилтетрахидрофолат

What is "Top Folate" and what it is used for.


"Top Folate" contains (6S)-5-methyltetrahydrofolate (MTXF), patented under the name Quatrefolic®. Quatrefolic® does not require metabolism because it is identical to the bioactive form of folic acid in the body. It is a pure and stable glucosamine salt of Methyltetrahydrofolic acid. (6S)-5-Methyltetrahydrofolate (MTXF) is of fundamental importance in the metabolic processes of the body.

  • This bioactive folate is up to seven times more bioavailable than folic acid. It is particularly important for people with a genetic deficit of folic acid metabolising enzymes because it does not need to be converted to become metabolically active.
  • In addition to genetic defects, the transformation of folic acid into the active form of folate may be compromised by both physiological stress and inappropriate lifestyle.
  • Unlike folic acid, 5-MTHF like Quatrefolic®  can cross the blood-brain barrier, which is particularly important for people with cognitive impairment as it helps with the enhancement of acetylcholine (a memory-associated neurotransmitter) synthesis in the brain.
  • Healthy diets with adequate intake of 5-MTHF Quatrefolic®   can reduce the risk of having a child with spinal cord defects. Research in recent years has shown the benefits of reduced folate forms over folic acid.
  • The use of reduced folate forms (reduced and methylated) is imperative in people who can not assimilate and metabolize folic acid from food and food supplements.

Recommended daily dose: 1 capsule “Top Folate” a day or as directed by your doctor.


Recommended intake time: Between meals.


Duration of intake: Best results are obtained with continual use.


Side Effects and Contraindications: To date, no side effects are known from Quatrefolic® use.


*Quatrefolic® is a registered trademark of Gnosis S.P.A.