TOP FOLATE - 20ML

Top Folate spray (Quatrefolic (6S) - 5 methyl tetrahydrofolate and glucosamine salt)

Packaging: 20 ml oral spray 

Dose: One spray per day !

Active ingredient: Quatrefolic (6S) - 5 methyl tetrahydrofolate and glucosamine salt

Quatrefolic is the latest fourth generation folate, consisting of (6S) -5-methyltetrahydrofolate and glucosamine salt.

The liquid form of the product has definite advantages and benefits for patients:

It is absorbed much faster by the body - between one and four minutes, unlike solid forms, which have a much slower metabolism.

Facilitated ingestion and ingestion, allowing supplementation in large doses.

Much more purified from excipients and agents formula used in capsule forms.

Recent worldwide studies show that more than 50% of people have a problem with the absorption of folic acid due to a defect in genes encoding the enzyme MTXFR (methyltetrahydrofolate reductase) - the main catalyst for the final active metabolite of folic acid. This on the one hand leads to deficiency in the body, and on the other to increased levels of non-metabolized products with a possible carcinogenic effect.

1. Folic acid deficiency leads to impaired DNA synthesis in the bone marrow and the development of megaloblastic anemia. Quatrefolic rapidly restores plasma folate levels and normal haematopoiesis.
2. High levels of homocysteine in the blood are associated with heart disease and stroke. Folic acid intake lowers homocysteine levels by 20% to 30% (in people with a plasma concentration of more than 11 micromoles / L.)
3. Reduces the harmful effects of drugs from the group of antiepileptics (phenobarbital, phenytoin) and cytostatics (methotrexate). Reduces nausea and vomiting as well as drug-induced folate deficiency.
4. Recent studies have shown that taking folic acid in higher doses, combined or not with antidepressants, improves symptoms in people with depression and dementia (especially markedly in old age). Quatrefolic freely crosses the blood-brain barrier.
5. Taking folic acid in doses over 1 mg daily reduces the risk of ischemic stroke by over 18%.
6. The high levels of non-metabolized folic acid that occur when supplementing with an older generation of folate suppress NK cell activity and the ability of the immune system to limit the development of colorectal cancer and cervical cancer. Quatrefolic does not lead to the accumulation of non-metabolised folate cycle products.
7. Quatrefolic as a source of [6S] -5-MethylTHF is extremely suitable for the delivery of the bioactive form of folic acid before onset, during pregnancy and lactation. Expectant mothers often do not know that they are pregnant and are not supplemented. Quatrefolic will increase plasma folate levels the fastest.
8. Maintaining high levels of folic acid improves ovarian function and affects idiopathic infertility.
9. Folic acid deficiency increases the risk of congenital malformations, spina bifida, miscarriages and Down syndrome.
10. Decreased levels of folic acid in the cerebrospinal fluid is associated with changes in brain function, including depression, due to decreased synthesis of neurotransmitters (acetylcholine). Quatrefolic is suitable for postpartum depression.
11. Breastfeeding women also need more folic acid (average 130 mcg more). Quatrefolic is more effective than regular folic acid at maintaining higher plasma levels.
12. The high levels of non-metabolized folic acid that occur when supplementing with an older generation of folate suppress NK cell activity and the ability of the immune system to limit the development of colorectal cancer and cervical cancer. Quatrefolic does not lead to the accumulation of non-metabolised folate cycle products.

BIONALITY

Quatrefolic is 100 times more soluble in water than the 3rd generation folate - 5 methyltetrahydrofolate calcium salt. This is due to the glucosamine salt.

STABILITY

After reconstitution, Quatrefolic has a neutral pH, which provides higher stability of the molecule, protecting it from hydrolytic degradation. The active substance can be stored at room temperature as opposed to the required 2-8 0C for storage of 3rd generation folate.

SAFETY

Quatrefolic is classified by the US Food and Drug Administration as GRAS - ie. completely safe to use.

MULTIFUNCTIONALITY

Quatrefolic is widely used in the treatment of various conditions and diseases. Taking one spray a day or as recommended by your doctor. Warning Do not exceed the recommended daily dose. The product is not a substitute for a varied diet. Food supplement.